Methyl ester of 6-methyl-2-phenylquinolin-4-carboxylic acid.



UNITED srAT s PATENT orricn.

noun, or isnnmir, GERMA Y, Ass'renon 'ro cnnmrscnn ramux AUF ncrrnn (vonm'n; scnnnms), or BERLIN, GERMANY.

METHYL Esrnnor. e-mE'rHYL-arrrrmrr.aumonm-ecamaoxrmc new.

1,045,379. no Drawing.

Specification of Letters Patent.

Patented Nov. 26, 1912.

Application filed June 15, 1912. Serial' m.7oa,e1s. v

have invented a new: and useful Improvement in Methyl Esters of 6-Methyl-2- ,Phenylquinolin-4-Carboxylic Acid, of which the following is a specification.

This invention relates to the manufacture of the methyl' ester of 6-methyl-2-phenylquinlin-4-carboxylic acid, which is useful in the treatment of gout and articular rheumatism. The ester has the following constitution copcns l T Yd I cu5 It crystallizes in white needles and melts at about 91 C. and is soluble in alcohol, ether and benzene and forms salts with The new product may be,obtained by esterification of the (i-methyI-Q-phenylquinolin-4-carboxylic acid, for instance; in: the following way: Dry hydrochloric acid gas is passed for some hours through a methyla'lcoholic solution of 6-methyl-2-phenylquinolin-a-carboxylic acid saturated in the cold with hydrochloric acid. The solution is precipitated with water, extracted with ether and the residuum of the ethereal solution recrystallized from alcohol.

I claim as my invention: The herein described methyl ester of 6- methyl-2-phenylquinolin-4-carboxylic acid,

melting at about 91 C., crystallizing in white needles, being soluble in alcohol, ether and benzene, and forming salts, substantially, as described. a

In testimony whereof I have hereunto set my handy in the presence of two subscribing witnesses. v

' MAX DOHRN. Witnesses:

HENRY HASPER, W onnnm HAUPT. 

